PeproTech 2017年11月發(fā)布重組人TLR-4等10種產品！
美國PeproTech公司是全球最大的重組細胞因子和蛋白生產商之一，始終致力于為生命科學研究開發(fā)重組蛋白及相關產品，如今已成為能提供多種高質量細胞因子和重組蛋白，相應的單克隆、多克隆和生物素標記抗體，以及ELISA試劑盒的世界領導者。PeproTech.的產品涵蓋免疫調節(jié)蛋白、白介素、集落刺激因子、生長因子、無動物成分的重組蛋白、化學趨化因子、干擾素、脂聯(lián)素、成纖維生長因子、轉化生長因子、腫瘤壞死因子、神經營養(yǎng)素和防御素等諸多生命科學研究領域中重要的生物活性分子。PeproTech公司的產品種類、規(guī)格齊全，更新速度快，且價格適中，已廣為中國的科研工作者所使用。
1.兔抗人Amphiregulin多抗 制備:Produced from sera of rabbits immunized with highly pure Recombinant Human Amphiregulin. Anti-Human Amphiregulin-specific antibody was purified by affinity chromatography employing an immobilized Human Amphiregulin matrix. 免疫原:E.coli derived Recombinant Human Amphiregulin (PeproTech catalog# 100-55B) 2.兔抗人Amphiregulin多抗 生物素標記 制備:Produced from sera of rabbits immunized with highly pure Recombinant Human Amphiregulin. Anti-Human Amphiregulin-specific antibody was purified by affinity chromatography and then biotinylated. 免疫原:E.coli derived Recombinant Human Amphiregulin (PeproTech catalog# 100-55B) 3.重組人Sclerostin 產品描述：Sclerostin, a glycoprotein predominantly secreted by osteocytes, is a member of the Cerberus/DAN family of putative BMP antagonists that functions as an endogenous regulator of the canonical Wnt signaling pathway and an inhibitory regulator of bone homeostasis.Sclerostin’s critical involvement in the regulation of bone formation and resorption is emphasized by two bone dysplasia disorders, sclerosteosis and van Buchem disease (VBD), caused by rare autosomal recessive mutations that result in progressive bone overgrowth and hypermineralization due to markedly decreased sclerostin levels. PeproTech's CHO cell-derived Recombinant Human Sclerostin is a 186-amino-acid-length glycoprotein with a calculated molecular weight of 21.0 kDa. 4.重組人I-TAC (CXCL11) 產品描述:I-TAC is a 'non-ELR' CXC chemokine that is regulated by interferon and signals through the CXCR3 receptor. I-TAC is chemoattractant for IL-2 activated T cells, but does not affect freshly isolated un-stimulated T cells, neutrophils, ormonocytes. Recombinant Human I-TAC (CXCL11) is an 8.3 kDa protein containing 73 amino acid residues, including the four highly conserved cysteine residues present in CXC chemokines. Manufactured using all Animal-Free reagents. 5.重組人TLR-4 產品描述:Characterized by N-terminal domains rich in leucine repeats and C-terminal intracellular Toll/interleukin (IL)-1 (TIL) domains, the structurally-related members of the Toll-like Receptor (TLR) family are abundantly expressed, transmembrane signaling receptors that play integral roles in the induction of innate and adaptive immunity. As members of the larger family of pattern recognition receptors, TLRs recognize and respond to pathogen-associated molecular patterns (PAMPs) and endogenous damage-associated molecular patterns (DAMPs) by initiating activation of NF-κB and the release of inflammatory mediators.Recombinant Human TLR-4 is a 69.3 kDa glycoprotein containing 609 amino acid residues of the TLR-4 extracellular domain. 6.重組人sTNF Receptor Type I 產品描述:TNFRI belongs to the TNFR superfamily of transmembrane proteins, and is expressed in most cell types. Binding of either TNF-α or TNF-β to TNFRI initiates a signal transduction pathway that results in the activation of the transduction factor NF-κB, whose target genes are involved in the regulation of inflammatory responses, and, in certain cells induce apoptosis. Soluble TNF Receptor I (sTNFRI) is capable of inhibiting TNF-α and TNF-β activities by acting as a decoy receptor that serves as a sink for the TNF ligands. The human TNFRI gene encodes for a 455 amino acid type I transmembrane protein, which contains a 21 amino acid signal sequence, a 190 amino acid extracellular domain, a 23 amino acid transmembrane domain, and a 221 amino acid cytoplasmic domain. Recombinant Human sTNF Receptor Type I is an 18.3 kDa protein (162 amino acid residues) comprising the cysteine-rich, ligand-binding portion of the extracellular domain of the TNFRI protein. 7.重組小鼠IL-36RA 產品描述:The IL-1 family is comprised of 11 structurally related ligands, including the recently re-named IL-36RA (IL-1F5), IL-36α (IL-1F6), IL-36β (IL-1F8), and IL-36γ (IL-1F9). The interaction of IL-36 ligands with the IL-1Rrp2 receptor (IL-1R6) can induce various activities, including dendritic cell maturation and activation. IL-36RA can antagonize the NF-κB signaling induced by either IL-36α, β or γ by binding to the IL-1Rrp2 receptor in a manner that prevents the initiation of functional signaling. Recombinant Murine IL-36RA is an E.coli-derived 16.9 kDa protein containing 154 amino acid residues. 8.重組小鼠IL-21 產品描述:IL-21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation. Its action generally enhances antigen-specific responses of immune cells. The biological effects of IL-21 include: inducing the differentiation of T-cell-stimulated B-cells into plasma cells and memory B-cells; the stimulation of IgG production in conjunction with IL-4; and the induction of apoptotic effects in naïve B-cells and stimulated B-cells in the absence of T-cell signaling. Additionally, IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells. Recombinant Murine IL-21 is a 15.0 kDa protein consisting of 130 amino acid residues. 9.重組人Human Apo-SAA1 產品描述:Serum amyloid A proteins (SAA) represents a family of apolipoproteins that circulates in association with high-density lipoproteins (HDL). The level of Apo-SAA, normally 1-5 μg/ml in plasma, increases 500-1000 fold within 24 hours of an inflammatory stimulus and, under these conditions, is the most abundant HDL apolipoprotein. The human SAA gene codes for a 122 amino acid nonglycosylated polypeptide, which contains an 18 amino acid N-terminal sequence. Recombinant Human Apo-SAA1 is an 11.7 kDa protein containing 105 amino acid residues. 10.重組人Semaphorin 3A Fc 產品描述:Semaphorins are a large group of structurally-related, secreted, GPI-anchored, transmembrane, cell-signaling molecules. Semaphorins primarily function as axon growth cone guidance factors during neuronal development. Semaphorin 3A acts as a chemo-repellent to axons, and an inhibitor of the growth of axons by signaling through receptors, Neuropilin-1 and Plexin-A. PeproTech's CHO cell-derived Recombinant Human Semaphorin 3A Fc is a glycosylated, disulfide-linked homodimer of 1,976 amino acid residues, which includes the SEMA domain, immunoglobulin c2-like domain, and the C-terminal basic Arg/Lys-rich domain of the mature sequence, as well as an 8-residue N-terminal His-tag and a 230-residue C-terminal Fc region linked by two glycines. Recombinant Human Semaphorin 3A Fc has a calculated molecular weight of 226.2 kDa and therefore runs above the 200kDa marker by SDS-PAGE analysis under nonreducing conditions. 歡迎各位科研工作者前來咨詢和訂購！ PeproTech將繼續(xù)支持您的科研工作，祝您工作順利！ |
相關公司：美國PeproTech(派普泰克)公司
聯(lián)系電話：40000 53055,0512 6832 5983
E-mail：peprotech.infochina@thermofisher.com
聯(lián)系電話：40000 53055,0512 6832 5983
E-mail：peprotech.infochina@thermofisher.com
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